Using Homology Groups in Input Molecules

You can use Pipette Sketcher to identify a location where changes will be restricted to members of a homology group. All parts of the molecule other than the homology group will remain stable. Homology groups can only be used in terminal locations (not as linkers).

Before you begin: You must be creating or editing an experiment. For more information about creating an experiment, see Creating and Running Experiments.
  1. While editing an experiment, cick .
    Pipette Sketcher opens.
  2. Use Pipette Sketcher to create the molecule you want to use as input for the experiment.

    Pipette Sketcher is a tool for drawing and editing chemistry in a browser. For more information about using Pipette Sketcher, click Help in the lower-right corner.

  3. Select a terminal atom, and then click the Search Chemistry icon:

  4. Click Homology Group and choose a group:

    Table 1. Homology Groups
    Name Description
    Acyclic Acyclic (chain)
    Carbacyclic Acyclic all-carbon
    Heteroacyclic Acyclic with at least one heteroatom
    Alkoxy Acyclic with carbon and oxygen
    Alkyl Acyclic all-carbon with all single bonds
    Alkenyl Acyclic all-carbon with double bond
    Alkynyl Acyclic all-carbon with triple bond
    Cyclic Cyclic (ring assembly)
    Heterocyclic Cyclic with at least one heteroatom
    Carbocyclic Cyclic all-carbon
    Cyclic, no Carbon Cyclic with no carbon
    Heteroaryl Heteroaromatic
    Aryl Aromatic all-carbon
    Cycloalkyl Cyclic nonaromatic all-carbon
    Cycloalkenyl Cyclic nonaromatic all-carbon with double bond

  5. Click Update to save and return to GTD.
    The location is labeled with the name of the homology group:

When you run the experiment, everything other than the homology group is preserved in the generated molecules. The structure from the homology group is highlighted in light blue when you view the molecule.